Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental ana...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Udai P., Singh, Sudha, Singh, Sukh Mahendra
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365093/
https://www.ncbi.nlm.nih.gov/pubmed/18475822
http://dx.doi.org/10.1155/MBD.1998.35
_version_ 1782154084310056960
author Singh, Udai P.
Singh, Sudha
Singh, Sukh Mahendra
author_facet Singh, Udai P.
Singh, Sudha
Singh, Sukh Mahendra
author_sort Singh, Udai P.
collection PubMed
description Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.
format Text
id pubmed-2365093
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-23650932008-05-12 Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil Singh, Udai P. Singh, Sudha Singh, Sukh Mahendra Met Based Drugs Research Article Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365093/ /pubmed/18475822 http://dx.doi.org/10.1155/MBD.1998.35 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Singh, Udai P.
Singh, Sudha
Singh, Sukh Mahendra
Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title_full Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title_fullStr Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title_full_unstemmed Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title_short Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil
title_sort synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365093/
https://www.ncbi.nlm.nih.gov/pubmed/18475822
http://dx.doi.org/10.1155/MBD.1998.35
work_keys_str_mv AT singhudaip synthesischaracterizationandantitumouractivityofmetalcomplexesof5carboxy2thiouracil
AT singhsudha synthesischaracterizationandantitumouractivityofmetalcomplexesof5carboxy2thiouracil
AT singhsukhmahendra synthesischaracterizationandantitumouractivityofmetalcomplexesof5carboxy2thiouracil

Ejemplares similares