Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives

Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the...

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Autores principales: Scozzafava, Andrea, Cavazza, Christine, Supuran, Claudiu T., Saramet, Ioana, Briganti, Fabrizio, Banciu, Mircea D.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365096/
https://www.ncbi.nlm.nih.gov/pubmed/18475819
http://dx.doi.org/10.1155/MBD.1998.11
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author Scozzafava, Andrea
Cavazza, Christine
Supuran, Claudiu T.
Saramet, Ioana
Briganti, Fabrizio
Banciu, Mircea D.
author_facet Scozzafava, Andrea
Cavazza, Christine
Supuran, Claudiu T.
Saramet, Ioana
Briganti, Fabrizio
Banciu, Mircea D.
author_sort Scozzafava, Andrea
collection PubMed
description Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the ligands were evidenced to interact with the metal ions in the prepared complexes. The original mercaptans and their metal complexes behave as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV, but did not lower intraocular pressure in rabbits in animal models of glaucoma.
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spelling pubmed-23650962008-05-12 Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives Scozzafava, Andrea Cavazza, Christine Supuran, Claudiu T. Saramet, Ioana Briganti, Fabrizio Banciu, Mircea D. Met Based Drugs Research Article Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the ligands were evidenced to interact with the metal ions in the prepared complexes. The original mercaptans and their metal complexes behave as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV, but did not lower intraocular pressure in rabbits in animal models of glaucoma. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365096/ /pubmed/18475819 http://dx.doi.org/10.1155/MBD.1998.11 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Scozzafava, Andrea
Cavazza, Christine
Supuran, Claudiu T.
Saramet, Ioana
Briganti, Fabrizio
Banciu, Mircea D.
Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title_full Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title_fullStr Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title_full_unstemmed Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title_short Complexes With Biologically Active Ligands. Part 11(1). Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives
title_sort complexes with biologically active ligands. part 11(1). synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365096/
https://www.ncbi.nlm.nih.gov/pubmed/18475819
http://dx.doi.org/10.1155/MBD.1998.11
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