Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds

Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in...

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Detalles Bibliográficos
Autores principales: Rima, Ghassoub, Satgé, Jacques, Dagiral, Rodolphe, Lion, Claude, Fatome, Marc, Roman, Vincent, Laval, Jean-Denis
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365109/
https://www.ncbi.nlm.nih.gov/pubmed/18475835
http://dx.doi.org/10.1155/MBD.1998.139
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author Rima, Ghassoub
Satgé, Jacques
Dagiral, Rodolphe
Lion, Claude
Fatome, Marc
Roman, Vincent
Laval, Jean-Denis
author_facet Rima, Ghassoub
Satgé, Jacques
Dagiral, Rodolphe
Lion, Claude
Fatome, Marc
Roman, Vincent
Laval, Jean-Denis
author_sort Rima, Ghassoub
collection PubMed
description Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.
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spelling pubmed-23651092008-05-12 Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds Rima, Ghassoub Satgé, Jacques Dagiral, Rodolphe Lion, Claude Fatome, Marc Roman, Vincent Laval, Jean-Denis Met Based Drugs Research Article Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365109/ /pubmed/18475835 http://dx.doi.org/10.1155/MBD.1998.139 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rima, Ghassoub
Satgé, Jacques
Dagiral, Rodolphe
Lion, Claude
Fatome, Marc
Roman, Vincent
Laval, Jean-Denis
Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title_full Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title_fullStr Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title_full_unstemmed Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title_short Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds
title_sort synthesis and radioprotective activity of new organosilicon and germanium compounds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365109/
https://www.ncbi.nlm.nih.gov/pubmed/18475835
http://dx.doi.org/10.1155/MBD.1998.139
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