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Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases

The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On...

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Detalles Bibliográficos
Autores principales: Liu, Weiping, Xiong, Huizhou, Yang, Yikun, Li, Ling, Shen, Zhiqiang, Chen, Zhihe
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365110/
https://www.ncbi.nlm.nih.gov/pubmed/18475833
http://dx.doi.org/10.1155/MBD.1998.123
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author Liu, Weiping
Xiong, Huizhou
Yang, Yikun
Li, Ling
Shen, Zhiqiang
Chen, Zhihe
author_facet Liu, Weiping
Xiong, Huizhou
Yang, Yikun
Li, Ling
Shen, Zhiqiang
Chen, Zhihe
author_sort Liu, Weiping
collection PubMed
description The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases.
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spelling pubmed-23651102008-05-12 Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases Liu, Weiping Xiong, Huizhou Yang, Yikun Li, Ling Shen, Zhiqiang Chen, Zhihe Met Based Drugs Research Article The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365110/ /pubmed/18475833 http://dx.doi.org/10.1155/MBD.1998.123 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Weiping
Xiong, Huizhou
Yang, Yikun
Li, Ling
Shen, Zhiqiang
Chen, Zhihe
Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title_full Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title_fullStr Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title_full_unstemmed Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title_short Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases
title_sort potential application of copper aspirinate in preventing and treating thromboembolic diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365110/
https://www.ncbi.nlm.nih.gov/pubmed/18475833
http://dx.doi.org/10.1155/MBD.1998.123
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