Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates

A number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph(3)P derivatives and species based...

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Detalles Bibliográficos
Autores principales: Whitehouse, Michael W., Cookson, Peter D., Siasios, George, Tiekink, Edward R. T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365125/
https://www.ncbi.nlm.nih.gov/pubmed/18475850
http://dx.doi.org/10.1155/MBD.1998.245
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author Whitehouse, Michael W.
Cookson, Peter D.
Siasios, George
Tiekink, Edward R. T.
author_facet Whitehouse, Michael W.
Cookson, Peter D.
Siasios, George
Tiekink, Edward R. T.
author_sort Whitehouse, Michael W.
collection PubMed
description A number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph(3)P derivatives and species based on thiopurines were the most effective and that with other complexes enhanced activity was accompanied by greater toxicity.
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spelling pubmed-23651252008-05-12 Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates Whitehouse, Michael W. Cookson, Peter D. Siasios, George Tiekink, Edward R. T. Met Based Drugs Research Article A number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph(3)P derivatives and species based on thiopurines were the most effective and that with other complexes enhanced activity was accompanied by greater toxicity. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365125/ /pubmed/18475850 http://dx.doi.org/10.1155/MBD.1998.245 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Whitehouse, Michael W.
Cookson, Peter D.
Siasios, George
Tiekink, Edward R. T.
Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title_full Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title_fullStr Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title_full_unstemmed Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title_short Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates
title_sort anti-arthritic activity in rats of some phosphinegold(i) thionucleobases and related thiolates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365125/
https://www.ncbi.nlm.nih.gov/pubmed/18475850
http://dx.doi.org/10.1155/MBD.1998.245
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AT siasiosgeorge antiarthriticactivityinratsofsomephosphinegoldithionucleobasesandrelatedthiolates
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