In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging

Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3−) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) f...

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Detalles Bibliográficos
Autores principales: Prata, M. I. M., Ribeiro, M. J., Santos, A. C., Peters, J. A., Nepveu, F., Geraldes, C. F. G. C., de Lima, J. J. P.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365140/
https://www.ncbi.nlm.nih.gov/pubmed/18475854
http://dx.doi.org/10.1155/MBD.1998.259
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author Prata, M. I. M.
Ribeiro, M. J.
Santos, A. C.
Peters, J. A.
Nepveu, F.
Geraldes, C. F. G. C.
de Lima, J. J. P.
author_facet Prata, M. I. M.
Ribeiro, M. J.
Santos, A. C.
Peters, J. A.
Nepveu, F.
Geraldes, C. F. G. C.
de Lima, J. J. P.
author_sort Prata, M. I. M.
collection PubMed
description Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3−) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) from the complexes to transferrin and the results were compared with those for (111)In(DTPA)(2−). We also performed biodistribution studies of the three (111)In(3+) complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion.
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spelling pubmed-23651402008-05-12 In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging Prata, M. I. M. Ribeiro, M. J. Santos, A. C. Peters, J. A. Nepveu, F. Geraldes, C. F. G. C. de Lima, J. J. P. Met Based Drugs Research Article Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3−) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) from the complexes to transferrin and the results were compared with those for (111)In(DTPA)(2−). We also performed biodistribution studies of the three (111)In(3+) complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365140/ /pubmed/18475854 http://dx.doi.org/10.1155/MBD.1998.259 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Prata, M. I. M.
Ribeiro, M. J.
Santos, A. C.
Peters, J. A.
Nepveu, F.
Geraldes, C. F. G. C.
de Lima, J. J. P.
In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title_full In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title_fullStr In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title_full_unstemmed In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title_short In Vitro and In Vivo Behaviour of (111)In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging
title_sort in vitro and in vivo behaviour of (111)in complexes of ttha, ttha-bis(butylamide) and ttha-bis(glucamide): stability, biodistribution and excretion studied by gamma imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365140/
https://www.ncbi.nlm.nih.gov/pubmed/18475854
http://dx.doi.org/10.1155/MBD.1998.259
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