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Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules
Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu(2)(Indo)(4)(DMF)(2) I crystallizes in space group P-1 (a = 10.829(2), b...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365144/ https://www.ncbi.nlm.nih.gov/pubmed/18475870 http://dx.doi.org/10.1155/MBD.1998.337 |
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author | Guessous, Fadila Daran, Jean-Claude Viossat, Bernard Morgant, Georges Labouze, Xavier Leroy, Anne Laure Roch-Arveiller, Monique Dung, Nguyen-Huy |
author_facet | Guessous, Fadila Daran, Jean-Claude Viossat, Bernard Morgant, Georges Labouze, Xavier Leroy, Anne Laure Roch-Arveiller, Monique Dung, Nguyen-Huy |
author_sort | Guessous, Fadila |
collection | PubMed |
description | Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu(2)(Indo)(4)(DMF)(2) I crystallizes in space group P-1 (a = 10.829(2), b = 13.379(2), c = 16.491(3) Å; α = 105.58(2), β = 101.06(2), γ = 106.96(2)°; V= 2104.6(6) Å(3), Z= 1). The title molecule is a centrosymmetric binuclear complex, with Cu atoms bridged by the carboxylate moieties of four indomethacinate ligands. The four nearest O atoms around each Cu atom form a square planar arrangement with the square pyramidal coordination completed by the O atom of N,N′-dimethylformamide. Daily administration for seven days of 1 mg/kg of indomethacin, I and I encapsulated into liposomes induces a weak inflammation of rat gastrointestinal tract. I was less inflammatory than indomethacin but the better protection was brought by encapsulation of the compound. This might be of interest in sustained therapies of chronic inflammatory diseases. |
format | Text |
id | pubmed-2365144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23651442008-05-12 Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules Guessous, Fadila Daran, Jean-Claude Viossat, Bernard Morgant, Georges Labouze, Xavier Leroy, Anne Laure Roch-Arveiller, Monique Dung, Nguyen-Huy Met Based Drugs Research Article Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu(2)(Indo)(4)(DMF)(2) I crystallizes in space group P-1 (a = 10.829(2), b = 13.379(2), c = 16.491(3) Å; α = 105.58(2), β = 101.06(2), γ = 106.96(2)°; V= 2104.6(6) Å(3), Z= 1). The title molecule is a centrosymmetric binuclear complex, with Cu atoms bridged by the carboxylate moieties of four indomethacinate ligands. The four nearest O atoms around each Cu atom form a square planar arrangement with the square pyramidal coordination completed by the O atom of N,N′-dimethylformamide. Daily administration for seven days of 1 mg/kg of indomethacin, I and I encapsulated into liposomes induces a weak inflammation of rat gastrointestinal tract. I was less inflammatory than indomethacin but the better protection was brought by encapsulation of the compound. This might be of interest in sustained therapies of chronic inflammatory diseases. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2365144/ /pubmed/18475870 http://dx.doi.org/10.1155/MBD.1998.337 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Guessous, Fadila Daran, Jean-Claude Viossat, Bernard Morgant, Georges Labouze, Xavier Leroy, Anne Laure Roch-Arveiller, Monique Dung, Nguyen-Huy Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules |
title | Ternary Copper(II) Complexes With Indomethacin, a Potent
Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis
(Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II).
Antiinflammatory Properties and
Prevention of Gastrointestinal Side Effects by Nanocapsules |
title_full | Ternary Copper(II) Complexes With Indomethacin, a Potent
Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis
(Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II).
Antiinflammatory Properties and
Prevention of Gastrointestinal Side Effects by Nanocapsules |
title_fullStr | Ternary Copper(II) Complexes With Indomethacin, a Potent
Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis
(Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II).
Antiinflammatory Properties and
Prevention of Gastrointestinal Side Effects by Nanocapsules |
title_full_unstemmed | Ternary Copper(II) Complexes With Indomethacin, a Potent
Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis
(Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II).
Antiinflammatory Properties and
Prevention of Gastrointestinal Side Effects by Nanocapsules |
title_short | Ternary Copper(II) Complexes With Indomethacin, a Potent
Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis
(Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II).
Antiinflammatory Properties and
Prevention of Gastrointestinal Side Effects by Nanocapsules |
title_sort | ternary copper(ii) complexes with indomethacin, a potent
non-steroidal antiinflammatory drug. crystal structure of bis
(dimethylformamide)-tetrakis[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-h-indole-3-acetato]dicopper(ii).
antiinflammatory properties and
prevention of gastrointestinal side effects by nanocapsules |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365144/ https://www.ncbi.nlm.nih.gov/pubmed/18475870 http://dx.doi.org/10.1155/MBD.1998.337 |
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