Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays

The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades wer...

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Autores principales: Gil, Eric de Souza, Gonçalves, Maria Inês de Almeida, Ferreira, Elizabeth Igne, Zyngier, Szulin Ber, Najjar, Renato
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365148/
https://www.ncbi.nlm.nih.gov/pubmed/18475876
http://dx.doi.org/10.1155/MBD.1999.19
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author Gil, Eric de Souza
Gonçalves, Maria Inês de Almeida
Ferreira, Elizabeth Igne
Zyngier, Szulin Ber
Najjar, Renato
author_facet Gil, Eric de Souza
Gonçalves, Maria Inês de Almeida
Ferreira, Elizabeth Igne
Zyngier, Szulin Ber
Najjar, Renato
author_sort Gil, Eric de Souza
collection PubMed
description The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.
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spelling pubmed-23651482008-05-12 Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays Gil, Eric de Souza Gonçalves, Maria Inês de Almeida Ferreira, Elizabeth Igne Zyngier, Szulin Ber Najjar, Renato Met Based Drugs Research Article The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365148/ /pubmed/18475876 http://dx.doi.org/10.1155/MBD.1999.19 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gil, Eric de Souza
Gonçalves, Maria Inês de Almeida
Ferreira, Elizabeth Igne
Zyngier, Szulin Ber
Najjar, Renato
Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title_full Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title_fullStr Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title_full_unstemmed Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title_short Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays
title_sort water soluble cyclophosphamide adducts of rhodium(ii) keto-gluconate and glucuronate. synthesis, characterization and in vitro cytostatic assays
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365148/
https://www.ncbi.nlm.nih.gov/pubmed/18475876
http://dx.doi.org/10.1155/MBD.1999.19
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