Biologically-Active Gold(III) Complexes

A review is given of the background to and results of the succesful pharmacological testing of [AuX(2)(damp)] (X = Cl, OAc; damp = 2−Me(2) NCH(2)C(6) H(4)) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) comp...

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Detalles Bibliográficos
Autor principal: Parish, R. V.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365175/
https://www.ncbi.nlm.nih.gov/pubmed/18475902
http://dx.doi.org/10.1155/MBD.1999.271
Descripción
Sumario:A review is given of the background to and results of the succesful pharmacological testing of [AuX(2)(damp)] (X = Cl, OAc; damp = 2−Me(2) NCH(2)C(6) H(4)) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) complexes. The activity and reactions of the diacetato-complex bear a resemblance to cisplatin, and some of the relevant chemistry is discussed. Preliminary screening data for C,P-chelated tertiary phosphine derivatives of gold(III) are presented.

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