Biologically-Active Gold(III) Complexes

A review is given of the background to and results of the succesful pharmacological testing of [AuX(2)(damp)] (X = Cl, OAc; damp = 2−Me(2) NCH(2)C(6) H(4)) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) comp...

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Detalles Bibliográficos
Autor principal: Parish, R. V.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365175/
https://www.ncbi.nlm.nih.gov/pubmed/18475902
http://dx.doi.org/10.1155/MBD.1999.271
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author Parish, R. V.
author_facet Parish, R. V.
author_sort Parish, R. V.
collection PubMed
description A review is given of the background to and results of the succesful pharmacological testing of [AuX(2)(damp)] (X = Cl, OAc; damp = 2−Me(2) NCH(2)C(6) H(4)) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) complexes. The activity and reactions of the diacetato-complex bear a resemblance to cisplatin, and some of the relevant chemistry is discussed. Preliminary screening data for C,P-chelated tertiary phosphine derivatives of gold(III) are presented.
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spelling pubmed-23651752008-05-12 Biologically-Active Gold(III) Complexes Parish, R. V. Met Based Drugs Research Article A review is given of the background to and results of the succesful pharmacological testing of [AuX(2)(damp)] (X = Cl, OAc; damp = 2−Me(2) NCH(2)C(6) H(4)) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) complexes. The activity and reactions of the diacetato-complex bear a resemblance to cisplatin, and some of the relevant chemistry is discussed. Preliminary screening data for C,P-chelated tertiary phosphine derivatives of gold(III) are presented. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365175/ /pubmed/18475902 http://dx.doi.org/10.1155/MBD.1999.271 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Parish, R. V.
Biologically-Active Gold(III) Complexes
title Biologically-Active Gold(III) Complexes
title_full Biologically-Active Gold(III) Complexes
title_fullStr Biologically-Active Gold(III) Complexes
title_full_unstemmed Biologically-Active Gold(III) Complexes
title_short Biologically-Active Gold(III) Complexes
title_sort biologically-active gold(iii) complexes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365175/
https://www.ncbi.nlm.nih.gov/pubmed/18475902
http://dx.doi.org/10.1155/MBD.1999.271
work_keys_str_mv AT parishrv biologicallyactivegoldiiicomplexes

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