Binding of Platinum(II) to Some Biologicaly Important Thiols

The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrovic, Biljana V., Djuran, Milos I., Bugarcic, Zivadin D.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365182/
https://www.ncbi.nlm.nih.gov/pubmed/18475912
http://dx.doi.org/10.1155/MBD.1999.355
Descripción
Sumario:The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06 x 10(-2) and 6.10 x 10(+3) M(-1) s(-1) at 25(°)C. The activation entropies have large negative values between -100 and -200 J mol(-1) which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes.

Ejemplares similares