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Binding of Platinum(II) to Some Biologicaly Important Thiols
The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365182/ https://www.ncbi.nlm.nih.gov/pubmed/18475912 http://dx.doi.org/10.1155/MBD.1999.355 |
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author | Petrovic, Biljana V. Djuran, Milos I. Bugarcic, Zivadin D. |
author_facet | Petrovic, Biljana V. Djuran, Milos I. Bugarcic, Zivadin D. |
author_sort | Petrovic, Biljana V. |
collection | PubMed |
description | The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06 x 10(-2) and 6.10 x 10(+3) M(-1) s(-1) at 25(°)C. The activation entropies have large negative values between -100 and -200 J mol(-1) which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes. |
format | Text |
id | pubmed-2365182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23651822008-05-12 Binding of Platinum(II) to Some Biologicaly Important Thiols Petrovic, Biljana V. Djuran, Milos I. Bugarcic, Zivadin D. Met Based Drugs Research Article The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06 x 10(-2) and 6.10 x 10(+3) M(-1) s(-1) at 25(°)C. The activation entropies have large negative values between -100 and -200 J mol(-1) which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365182/ /pubmed/18475912 http://dx.doi.org/10.1155/MBD.1999.355 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Petrovic, Biljana V. Djuran, Milos I. Bugarcic, Zivadin D. Binding of Platinum(II) to Some Biologicaly Important Thiols |
title | Binding of Platinum(II) to Some Biologicaly Important Thiols |
title_full | Binding of Platinum(II) to Some Biologicaly Important Thiols |
title_fullStr | Binding of Platinum(II) to Some Biologicaly Important Thiols |
title_full_unstemmed | Binding of Platinum(II) to Some Biologicaly Important Thiols |
title_short | Binding of Platinum(II) to Some Biologicaly Important Thiols |
title_sort | binding of platinum(ii) to some biologicaly important thiols |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365182/ https://www.ncbi.nlm.nih.gov/pubmed/18475912 http://dx.doi.org/10.1155/MBD.1999.355 |
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