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Binding of Platinum(II) to Some Biologicaly Important Thiols

The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06...

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Detalles Bibliográficos
Autores principales: Petrovic, Biljana V., Djuran, Milos I., Bugarcic, Zivadin D.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365182/
https://www.ncbi.nlm.nih.gov/pubmed/18475912
http://dx.doi.org/10.1155/MBD.1999.355
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author Petrovic, Biljana V.
Djuran, Milos I.
Bugarcic, Zivadin D.
author_facet Petrovic, Biljana V.
Djuran, Milos I.
Bugarcic, Zivadin D.
author_sort Petrovic, Biljana V.
collection PubMed
description The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06 x 10(-2) and 6.10 x 10(+3) M(-1) s(-1) at 25(°)C. The activation entropies have large negative values between -100 and -200 J mol(-1) which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes.
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spelling pubmed-23651822008-05-12 Binding of Platinum(II) to Some Biologicaly Important Thiols Petrovic, Biljana V. Djuran, Milos I. Bugarcic, Zivadin D. Met Based Drugs Research Article The reactions between [Pt(terpy)Cl(+) and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K(2), are similar for these four thiols, varying between 1.06 x 10(-2) and 6.10 x 10(+3) M(-1) s(-1) at 25(°)C. The activation entropies have large negative values between -100 and -200 J mol(-1) which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365182/ /pubmed/18475912 http://dx.doi.org/10.1155/MBD.1999.355 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Petrovic, Biljana V.
Djuran, Milos I.
Bugarcic, Zivadin D.
Binding of Platinum(II) to Some Biologicaly Important Thiols
title Binding of Platinum(II) to Some Biologicaly Important Thiols
title_full Binding of Platinum(II) to Some Biologicaly Important Thiols
title_fullStr Binding of Platinum(II) to Some Biologicaly Important Thiols
title_full_unstemmed Binding of Platinum(II) to Some Biologicaly Important Thiols
title_short Binding of Platinum(II) to Some Biologicaly Important Thiols
title_sort binding of platinum(ii) to some biologicaly important thiols
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365182/
https://www.ncbi.nlm.nih.gov/pubmed/18475912
http://dx.doi.org/10.1155/MBD.1999.355
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