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A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R(3) PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine
The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365188/ https://www.ncbi.nlm.nih.gov/pubmed/18475913 http://dx.doi.org/10.1155/MBD.1999.361 |
| _version_ | 1782154107940765696 |
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| author | Crump, David Siasios, George Tiekink, Edward R. T. |
| author_facet | Crump, David Siasios, George Tiekink, Edward R. T. |
| author_sort | Crump, David |
| collection | PubMed |
| description | The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy(3) PAu(6-MP)] and [Et(3)PAu(6-TG)]. |
| format | Text |
| id | pubmed-2365188 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1999 |
| publisher | Hindawi Publishing Corporation |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-23651882008-05-12 A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R(3) PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine Crump, David Siasios, George Tiekink, Edward R. T. Met Based Drugs Research Article The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy(3) PAu(6-MP)] and [Et(3)PAu(6-TG)]. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365188/ /pubmed/18475913 http://dx.doi.org/10.1155/MBD.1999.361 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Crump, David Siasios, George Tiekink, Edward R. T. A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R(3) PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine |
| title | A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R(3)
PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine
and R = Et; SR′H =
6-Thioguanine |
| title_full | A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R(3)
PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine
and R = Et; SR′H =
6-Thioguanine |
| title_fullStr | A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R(3)
PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine
and R = Et; SR′H =
6-Thioguanine |
| title_full_unstemmed | A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R(3)
PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine
and R = Et; SR′H =
6-Thioguanine |
| title_short | A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R(3)
PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine
and R = Et; SR′H =
6-Thioguanine |
| title_sort | study of the antitumour activity of four
triorganophosphinegold(i) thiolates: r(3)
pau(sr′), r = ph, cy, et; sr′h = 6-mercaptopurine
and r = et; sr′h =
6-thioguanine |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365188/ https://www.ncbi.nlm.nih.gov/pubmed/18475913 http://dx.doi.org/10.1155/MBD.1999.361 |
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