The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice

The boronated aromatic amino acids were shown to be potent hypolipidemic agents in mice lowering both serum cholesterol and triglycerides after 16 days. Selective compounds were as effective as the clinical standards. Furthermore, the compounds were effective anti-inflammatory agents reducing local...

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Detalles Bibliográficos
Autores principales: Miller, Merrill C., Sood, A., Spielvogel, Bernard F., Hall, Iris H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365189/
https://www.ncbi.nlm.nih.gov/pubmed/18475910
http://dx.doi.org/10.1155/MBD.1999.337
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author Miller, Merrill C.
Sood, A.
Spielvogel, Bernard F.
Hall, Iris H.
author_facet Miller, Merrill C.
Sood, A.
Spielvogel, Bernard F.
Hall, Iris H.
author_sort Miller, Merrill C.
collection PubMed
description The boronated aromatic amino acids were shown to be potent hypolipidemic agents in mice lowering both serum cholesterol and triglycerides after 16 days. Selective compounds were as effective as the clinical standards. Furthermore, the compounds were effective anti-inflammatory agents reducing local and central pain as well as suppressing LPS induced endotoxic shock in mice. These agents inhibited lysosomal and proteolytic enzymes of the liver and macrophages as a part of their mechanism of action.
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spelling pubmed-23651892008-05-12 The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice Miller, Merrill C. Sood, A. Spielvogel, Bernard F. Hall, Iris H. Met Based Drugs Research Article The boronated aromatic amino acids were shown to be potent hypolipidemic agents in mice lowering both serum cholesterol and triglycerides after 16 days. Selective compounds were as effective as the clinical standards. Furthermore, the compounds were effective anti-inflammatory agents reducing local and central pain as well as suppressing LPS induced endotoxic shock in mice. These agents inhibited lysosomal and proteolytic enzymes of the liver and macrophages as a part of their mechanism of action. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2365189/ /pubmed/18475910 http://dx.doi.org/10.1155/MBD.1999.337 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Miller, Merrill C.
Sood, A.
Spielvogel, Bernard F.
Hall, Iris H.
The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title_full The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title_fullStr The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title_full_unstemmed The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title_short The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice
title_sort hypolipidemic and anti-inflammatory activity of boronated aromatic amino acids in cf(1) male mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365189/
https://www.ncbi.nlm.nih.gov/pubmed/18475910
http://dx.doi.org/10.1155/MBD.1999.337
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