Biological Activity of Some Magnesium(II) Complexes of Quinolones

A new magnesium complex of quinolone antibacterial agent was prepared. This new complex as well as a previously isolated complex of magnesium with ciprofloxacin were tested against various Gram positive and Gram negative microorganisms. Antimicrobial activities were evaluated using the agar diffusio...

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Autores principales: Turel, Iztok, Šonc, Andrej, Zupančič, Marija, Sepčić, Kristina, Turk, Tom
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365201/
https://www.ncbi.nlm.nih.gov/pubmed/18475931
http://dx.doi.org/10.1155/MBD.2000.101
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author Turel, Iztok
Šonc, Andrej
Zupančič, Marija
Sepčić, Kristina
Turk, Tom
author_facet Turel, Iztok
Šonc, Andrej
Zupančič, Marija
Sepčić, Kristina
Turk, Tom
author_sort Turel, Iztok
collection PubMed
description A new magnesium complex of quinolone antibacterial agent was prepared. This new complex as well as a previously isolated complex of magnesium with ciprofloxacin were tested against various Gram positive and Gram negative microorganisms. Antimicrobial activities were evaluated using the agar diffusion test. The results have shown that all magnesium complexes are significantly less active than the parent quinolone drugs. It was also found that the activity of quinolones is reduced when the solutions of quinolones are titrated with magnesium ions.
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spelling pubmed-23652012008-05-12 Biological Activity of Some Magnesium(II) Complexes of Quinolones Turel, Iztok Šonc, Andrej Zupančič, Marija Sepčić, Kristina Turk, Tom Met Based Drugs Research Article A new magnesium complex of quinolone antibacterial agent was prepared. This new complex as well as a previously isolated complex of magnesium with ciprofloxacin were tested against various Gram positive and Gram negative microorganisms. Antimicrobial activities were evaluated using the agar diffusion test. The results have shown that all magnesium complexes are significantly less active than the parent quinolone drugs. It was also found that the activity of quinolones is reduced when the solutions of quinolones are titrated with magnesium ions. Hindawi Publishing Corporation 2000 /pmc/articles/PMC2365201/ /pubmed/18475931 http://dx.doi.org/10.1155/MBD.2000.101 Text en Copyright © 2000 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Turel, Iztok
Šonc, Andrej
Zupančič, Marija
Sepčić, Kristina
Turk, Tom
Biological Activity of Some Magnesium(II) Complexes of Quinolones
title Biological Activity of Some Magnesium(II) Complexes of Quinolones
title_full Biological Activity of Some Magnesium(II) Complexes of Quinolones
title_fullStr Biological Activity of Some Magnesium(II) Complexes of Quinolones
title_full_unstemmed Biological Activity of Some Magnesium(II) Complexes of Quinolones
title_short Biological Activity of Some Magnesium(II) Complexes of Quinolones
title_sort biological activity of some magnesium(ii) complexes of quinolones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365201/
https://www.ncbi.nlm.nih.gov/pubmed/18475931
http://dx.doi.org/10.1155/MBD.2000.101
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