Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors

Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)(2) and Zn(asp)(2), are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti-HSV drugs, further studies on th...

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Detalles Bibliográficos
Autores principales: Pesheva, Margarita, Varadinova, Tatiana
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365211/
https://www.ncbi.nlm.nih.gov/pubmed/18475935
http://dx.doi.org/10.1155/MBD.2000.129
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author Pesheva, Margarita
Varadinova, Tatiana
author_facet Pesheva, Margarita
Varadinova, Tatiana
author_sort Pesheva, Margarita
collection PubMed
description Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)(2) and Zn(asp)(2), are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti-HSV drugs, further studies on their mutagenicity are of particular interest. In the present paper we present data showing that Zn(pic)(2) and Zn(asp)(2) do not express mutagenic effect in both prokaryotic (Salmonella typhimurium) and eukaryotic (Saccharomices cerevisiae) test systems.
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spelling pubmed-23652112008-05-12 Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors Pesheva, Margarita Varadinova, Tatiana Met Based Drugs Research Article Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)(2) and Zn(asp)(2), are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti-HSV drugs, further studies on their mutagenicity are of particular interest. In the present paper we present data showing that Zn(pic)(2) and Zn(asp)(2) do not express mutagenic effect in both prokaryotic (Salmonella typhimurium) and eukaryotic (Saccharomices cerevisiae) test systems. Hindawi Publishing Corporation 2000 /pmc/articles/PMC2365211/ /pubmed/18475935 http://dx.doi.org/10.1155/MBD.2000.129 Text en Copyright © 2000 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pesheva, Margarita
Varadinova, Tatiana
Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title_full Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title_fullStr Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title_full_unstemmed Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title_short Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors
title_sort zinc(ii) complexes - a new group of non-mutagenic herpes simplex virus inhibitors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365211/
https://www.ncbi.nlm.nih.gov/pubmed/18475935
http://dx.doi.org/10.1155/MBD.2000.129
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AT varadinovatatiana zinciicomplexesanewgroupofnonmutagenicherpessimplexvirusinhibitors

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