Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are form...

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Detalles Bibliográficos
Autores principales: Lapi, Andrea, Pratviel, Geneviève, Meunier, Bernard
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365246/
https://www.ncbi.nlm.nih.gov/pubmed/18475975
http://dx.doi.org/10.1155/MBD.2001.47
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author Lapi, Andrea
Pratviel, Geneviève
Meunier, Bernard
author_facet Lapi, Andrea
Pratviel, Geneviève
Meunier, Bernard
author_sort Lapi, Andrea
collection PubMed
description In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.
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spelling pubmed-23652462008-05-12 Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways Lapi, Andrea Pratviel, Geneviève Meunier, Bernard Met Based Drugs Research Article In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2365246/ /pubmed/18475975 http://dx.doi.org/10.1155/MBD.2001.47 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lapi, Andrea
Pratviel, Geneviève
Meunier, Bernard
Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title_full Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title_fullStr Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title_full_unstemmed Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title_short Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
title_sort guanine oxidation in double-stranded dna by mntmpyp/khso(5): at least three independent reaction pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365246/
https://www.ncbi.nlm.nih.gov/pubmed/18475975
http://dx.doi.org/10.1155/MBD.2001.47
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AT meunierbernard guanineoxidationindoublestrandeddnabymntmpypkhso5atleastthreeindependentreactionpathways

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