Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis

Antithrombotic effect of the copper-aspirin complex (dimeric copper(II) bis(o-acetoxybenzoate) was evaluated in the model of venous thrombosis; its effects on platelet-neutrophil adhesion were investigated by use of rosette assay. The results showed that the intragastrically administered copper-aspi...

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Detalles Bibliográficos
Autores principales: Shen, Zhiqiang, Wu, Lanou, Liu, Weiping, Liu, Jikai, Chen, Zhihhe
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365252/
https://www.ncbi.nlm.nih.gov/pubmed/18475982
http://dx.doi.org/10.1155/MBD.2001.103
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author Shen, Zhiqiang
Wu, Lanou
Liu, Weiping
Liu, Jikai
Chen, Zhihhe
author_facet Shen, Zhiqiang
Wu, Lanou
Liu, Weiping
Liu, Jikai
Chen, Zhihhe
author_sort Shen, Zhiqiang
collection PubMed
description Antithrombotic effect of the copper-aspirin complex (dimeric copper(II) bis(o-acetoxybenzoate) was evaluated in the model of venous thrombosis; its effects on platelet-neutrophil adhesion were investigated by use of rosette assay. The results showed that the intragastrically administered copper-aspirin complex (5, 7, and 10 mg kg(-1)) dose-dependently lowered the wet and dry thrombus weight; it significantly decreased the binding of arachidonic acid-activated platelets to neutrophils with an IC(50) value of 41.5 μmol L(-1). The results suggested that copper aspirinate inhibited platelet-neutrophil adhesion and resulted in a more potent antithrombotic activity.
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spelling pubmed-23652522008-05-12 Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis Shen, Zhiqiang Wu, Lanou Liu, Weiping Liu, Jikai Chen, Zhihhe Met Based Drugs Research Article Antithrombotic effect of the copper-aspirin complex (dimeric copper(II) bis(o-acetoxybenzoate) was evaluated in the model of venous thrombosis; its effects on platelet-neutrophil adhesion were investigated by use of rosette assay. The results showed that the intragastrically administered copper-aspirin complex (5, 7, and 10 mg kg(-1)) dose-dependently lowered the wet and dry thrombus weight; it significantly decreased the binding of arachidonic acid-activated platelets to neutrophils with an IC(50) value of 41.5 μmol L(-1). The results suggested that copper aspirinate inhibited platelet-neutrophil adhesion and resulted in a more potent antithrombotic activity. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2365252/ /pubmed/18475982 http://dx.doi.org/10.1155/MBD.2001.103 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shen, Zhiqiang
Wu, Lanou
Liu, Weiping
Liu, Jikai
Chen, Zhihhe
Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title_full Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title_fullStr Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title_full_unstemmed Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title_short Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis
title_sort inhibitory effects of dimeric copper(ii) bis(o-acetoxybenzoate) on platelet-neutrophil adhesion and thrombosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365252/
https://www.ncbi.nlm.nih.gov/pubmed/18475982
http://dx.doi.org/10.1155/MBD.2001.103
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