Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents

Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (β-triethy...

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Autores principales: Rubina, Kira, Abele, Edgars, Arsenyan, Pavel, Abele, Ramona, Veveris, Maris, Lukevics, Edmunds
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365258/
https://www.ncbi.nlm.nih.gov/pubmed/18475980
http://dx.doi.org/10.1155/MBD.2001.85
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author Rubina, Kira
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Veveris, Maris
Lukevics, Edmunds
author_facet Rubina, Kira
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Veveris, Maris
Lukevics, Edmunds
author_sort Rubina, Kira
collection PubMed
description Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (β-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(β-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.
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spelling pubmed-23652582008-05-12 Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents Rubina, Kira Abele, Edgars Arsenyan, Pavel Abele, Ramona Veveris, Maris Lukevics, Edmunds Met Based Drugs Research Article Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (β-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(β-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2365258/ /pubmed/18475980 http://dx.doi.org/10.1155/MBD.2001.85 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rubina, Kira
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Veveris, Maris
Lukevics, Edmunds
Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title_full Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title_fullStr Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title_full_unstemmed Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title_short Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
title_sort synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365258/
https://www.ncbi.nlm.nih.gov/pubmed/18475980
http://dx.doi.org/10.1155/MBD.2001.85
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