Cytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, agai...

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Detalles Bibliográficos
Autores principales: Vincent, Beverly R., Clarke, David J., Smyth, Douglas R., de Vos, Dick, Tiekink, Edward R. T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365259/
https://www.ncbi.nlm.nih.gov/pubmed/18475979
http://dx.doi.org/10.1155/MBD.2001.79
Descripción
Sumario:The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID(50) 250 – 2500 ng/ml).

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