Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas

The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[...

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Autores principales: Salas, Juan M., Quirós, Miguel, Abul Haj, Mohammad, Magán, Rosa, Marín, Clotilde, Sáchez-Moreno, Manuel, Faure, René
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365262/
https://www.ncbi.nlm.nih.gov/pubmed/18475985
http://dx.doi.org/10.1155/MBD.2001.119
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author Salas, Juan M.
Quirós, Miguel
Abul Haj, Mohammad
Magán, Rosa
Marín, Clotilde
Sáchez-Moreno, Manuel
Faure, René
author_facet Salas, Juan M.
Quirós, Miguel
Abul Haj, Mohammad
Magán, Rosa
Marín, Clotilde
Sáchez-Moreno, Manuel
Faure, René
author_sort Salas, Juan M.
collection PubMed
description The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[PtCl(2)(7HtpO)(2)].2H(2)O has been solved by X-ray diffraction analysis. In vitro activity of the new isolated complexes against the epimastigote form of T. cruzi, procyclic form of T. b. brucei and promastigote form of L. donnovani and P. characias has also been studied. The three complexes markedly affect the growth of the parasites and none of them shows cytotoxicity against macrophage of the J774.2 line at the heaviest dosages used.
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spelling pubmed-23652622008-05-12 Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas Salas, Juan M. Quirós, Miguel Abul Haj, Mohammad Magán, Rosa Marín, Clotilde Sáchez-Moreno, Manuel Faure, René Met Based Drugs Research Article The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[PtCl(2)(7HtpO)(2)].2H(2)O has been solved by X-ray diffraction analysis. In vitro activity of the new isolated complexes against the epimastigote form of T. cruzi, procyclic form of T. b. brucei and promastigote form of L. donnovani and P. characias has also been studied. The three complexes markedly affect the growth of the parasites and none of them shows cytotoxicity against macrophage of the J774.2 line at the heaviest dosages used. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2365262/ /pubmed/18475985 http://dx.doi.org/10.1155/MBD.2001.119 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salas, Juan M.
Quirós, Miguel
Abul Haj, Mohammad
Magán, Rosa
Marín, Clotilde
Sáchez-Moreno, Manuel
Faure, René
Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title_full Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title_fullStr Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title_full_unstemmed Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title_short Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas
title_sort activity of pt(ii) and ru(iii) triazolopyrimidine complexes against parasites of the genus leishmania, trypanosomas and phytomonas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365262/
https://www.ncbi.nlm.nih.gov/pubmed/18475985
http://dx.doi.org/10.1155/MBD.2001.119
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