Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates

Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by (1)H, (13)C and (119)Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida...

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Autores principales: Smicka, A., Buchta, V., Handlir, K.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365265/
https://www.ncbi.nlm.nih.gov/pubmed/18475991
http://dx.doi.org/10.1155/MBD.2001.165
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author Smicka, A.
Buchta, V.
Handlir, K.
author_facet Smicka, A.
Buchta, V.
Handlir, K.
author_sort Smicka, A.
collection PubMed
description Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by (1)H, (13)C and (119)Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes) and their activity is comparable with that of some antifungal drugs commonly used in the clinical use like ketoconazole. The structure-activity relationships in these compounds are discussed.
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spelling pubmed-23652652008-05-12 Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates Smicka, A. Buchta, V. Handlir, K. Met Based Drugs Research Article Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by (1)H, (13)C and (119)Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes) and their activity is comparable with that of some antifungal drugs commonly used in the clinical use like ketoconazole. The structure-activity relationships in these compounds are discussed. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2365265/ /pubmed/18475991 http://dx.doi.org/10.1155/MBD.2001.165 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Smicka, A.
Buchta, V.
Handlir, K.
Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title_full Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title_fullStr Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title_full_unstemmed Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title_short Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates
title_sort synthesis, characterization and in vitro antifungal effect of some butyltin(iv) n-substituted 2-aminoethanethiolates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365265/
https://www.ncbi.nlm.nih.gov/pubmed/18475991
http://dx.doi.org/10.1155/MBD.2001.165
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