Synthesis, Characterization and Biological Activity of Dimethyltin Dicarboxylates Containing Germanium

A series of diorganotin dicarboxylates of the general formula (CH(3))(2)Sn(OCOCHR(3)CHR(2)GeR(1))(2) where R(1)=(C(6)H(5))(3), (P-CH(3)C(6)H(4))3, N(CH(2)CH(2)O)(3), R(2)=C(6)H(5), H, CH(3), P-CH(3)OC(6)H(4), P-ClC(6)H(4), P-CH(3)C(6)H(4), R(3)=CH(3) and H, have been synthesized by the reaction of d...

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Detalles Bibliográficos
Autores principales: Choudhary, M. A., Mazhar, M., Ali, S., Song, X., Eng, G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365275/
https://www.ncbi.nlm.nih.gov/pubmed/18476006
http://dx.doi.org/10.1155/MBD.2002.275
Descripción
Sumario:A series of diorganotin dicarboxylates of the general formula (CH(3))(2)Sn(OCOCHR(3)CHR(2)GeR(1))(2) where R(1)=(C(6)H(5))(3), (P-CH(3)C(6)H(4))3, N(CH(2)CH(2)O)(3), R(2)=C(6)H(5), H, CH(3), P-CH(3)OC(6)H(4), P-ClC(6)H(4), P-CH(3)C(6)H(4), R(3)=CH(3) and H, have been synthesized by the reaction of dimethyltin oxide with germanium substituted propionic acid in 1:2 molar ratio in toluene. The H(2)O formed was removed azeotropically using a Dean and Stark apparatus. All the compounds have been characterized by IR, multinuclear ((1)H, (13)C, (119)Sn) NMR, mass and Mössbauer spectroscopies. All compounds were found to have potential activity against bacteria.

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