Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(−1)) markedly promo...

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Detalles Bibliográficos
Autores principales: Li, Ling, Shen, Zhiqiang, Yang, Weimin, Wu, Wanling, Liu, Weiping, Chen, Zhihe
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365276/
https://www.ncbi.nlm.nih.gov/pubmed/18476002
http://dx.doi.org/10.1155/MBD.2002.253
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author Li, Ling
Shen, Zhiqiang
Yang, Weimin
Wu, Wanling
Liu, Weiping
Chen, Zhihe
author_facet Li, Ling
Shen, Zhiqiang
Yang, Weimin
Wu, Wanling
Liu, Weiping
Chen, Zhihe
author_sort Li, Ling
collection PubMed
description The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(−1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.
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spelling pubmed-23652762008-05-12 Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils Li, Ling Shen, Zhiqiang Yang, Weimin Wu, Wanling Liu, Weiping Chen, Zhihe Met Based Drugs Research Article The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(−1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365276/ /pubmed/18476002 http://dx.doi.org/10.1155/MBD.2002.253 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Ling
Shen, Zhiqiang
Yang, Weimin
Wu, Wanling
Liu, Weiping
Chen, Zhihe
Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title_full Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title_fullStr Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title_full_unstemmed Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title_short Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils
title_sort cerebroprotective effects of dimeric copper(ii) bis(o-acetoxybenzoate) on ischemia-reperfusion injury in gerbils
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365276/
https://www.ncbi.nlm.nih.gov/pubmed/18476002
http://dx.doi.org/10.1155/MBD.2002.253
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