Antifungal Activity of Solventlessly Synthesized Organomercurials

A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K(2)CO(3) under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from worku...

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Detalles Bibliográficos
Autores principales: Kidwai, M., Venkataramanan, R., Dave, B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365284/
https://www.ncbi.nlm.nih.gov/pubmed/18476007
http://dx.doi.org/10.1155/MBD.2002.283
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author Kidwai, M.
Venkataramanan, R.
Dave, B.
author_facet Kidwai, M.
Venkataramanan, R.
Dave, B.
author_sort Kidwai, M.
collection PubMed
description A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K(2)CO(3) under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time reduced from hours to minutes. The prepared compounds were tested against A. niger and A. flavous for their antifungal activity and were found to posses good activity.
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spelling pubmed-23652842008-05-12 Antifungal Activity of Solventlessly Synthesized Organomercurials Kidwai, M. Venkataramanan, R. Dave, B. Met Based Drugs Research Article A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K(2)CO(3) under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time reduced from hours to minutes. The prepared compounds were tested against A. niger and A. flavous for their antifungal activity and were found to posses good activity. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365284/ /pubmed/18476007 http://dx.doi.org/10.1155/MBD.2002.283 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kidwai, M.
Venkataramanan, R.
Dave, B.
Antifungal Activity of Solventlessly Synthesized Organomercurials
title Antifungal Activity of Solventlessly Synthesized Organomercurials
title_full Antifungal Activity of Solventlessly Synthesized Organomercurials
title_fullStr Antifungal Activity of Solventlessly Synthesized Organomercurials
title_full_unstemmed Antifungal Activity of Solventlessly Synthesized Organomercurials
title_short Antifungal Activity of Solventlessly Synthesized Organomercurials
title_sort antifungal activity of solventlessly synthesized organomercurials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365284/
https://www.ncbi.nlm.nih.gov/pubmed/18476007
http://dx.doi.org/10.1155/MBD.2002.283
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AT venkataramananr antifungalactivityofsolventlesslysynthesizedorganomercurials
AT daveb antifungalactivityofsolventlesslysynthesizedorganomercurials

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