Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives

O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR’R”(2), Ph(3)SnOSPR’R”(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”=...

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Autores principales: López-Cardoso, Marcela, García, Patricia García y, Cea-Olivares, Raymundo, Villareal, María- Luisa
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365286/
https://www.ncbi.nlm.nih.gov/pubmed/18476015
http://dx.doi.org/10.1155/MBD.2002.333
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author López-Cardoso, Marcela
García, Patricia García y
Cea-Olivares, Raymundo
Villareal, María- Luisa
author_facet López-Cardoso, Marcela
García, Patricia García y
Cea-Olivares, Raymundo
Villareal, María- Luisa
author_sort López-Cardoso, Marcela
collection PubMed
description O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR’R”(2), Ph(3)SnOSPR’R”(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.
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spelling pubmed-23652862008-05-12 Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives López-Cardoso, Marcela García, Patricia García y Cea-Olivares, Raymundo Villareal, María- Luisa Met Based Drugs Research Article O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR’R”(2), Ph(3)SnOSPR’R”(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365286/ /pubmed/18476015 http://dx.doi.org/10.1155/MBD.2002.333 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
López-Cardoso, Marcela
García, Patricia García y
Cea-Olivares, Raymundo
Villareal, María- Luisa
Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title_full Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title_fullStr Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title_full_unstemmed Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title_short Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives
title_sort cytotoxic activities of o-cholesteryl-o-phenyl-n-phenylphosphoramidate and its organometallic tin(lv) derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365286/
https://www.ncbi.nlm.nih.gov/pubmed/18476015
http://dx.doi.org/10.1155/MBD.2002.333
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