Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents

Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl a...

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Autores principales: Abele, Edgars, Rubina, Kira, Abele, Ramona, Dzenitis, Olegs, Arsenyan, Pavel, Popelis, Juris, Veveris, Maris, Meirena, Dainuvite, Lukevics, Edmunds
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365289/
https://www.ncbi.nlm.nih.gov/pubmed/18476011
http://dx.doi.org/10.1155/MBD.2002.307
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author Abele, Edgars
Rubina, Kira
Abele, Ramona
Dzenitis, Olegs
Arsenyan, Pavel
Popelis, Juris
Veveris, Maris
Meirena, Dainuvite
Lukevics, Edmunds
author_facet Abele, Edgars
Rubina, Kira
Abele, Ramona
Dzenitis, Olegs
Arsenyan, Pavel
Popelis, Juris
Veveris, Maris
Meirena, Dainuvite
Lukevics, Edmunds
author_sort Abele, Edgars
collection PubMed
description Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
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spelling pubmed-23652892008-05-12 Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents Abele, Edgars Rubina, Kira Abele, Ramona Dzenitis, Olegs Arsenyan, Pavel Popelis, Juris Veveris, Maris Meirena, Dainuvite Lukevics, Edmunds Met Based Drugs Research Article Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365289/ /pubmed/18476011 http://dx.doi.org/10.1155/MBD.2002.307 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abele, Edgars
Rubina, Kira
Abele, Ramona
Dzenitis, Olegs
Arsenyan, Pavel
Popelis, Juris
Veveris, Maris
Meirena, Dainuvite
Lukevics, Edmunds
Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title_full Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title_fullStr Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title_full_unstemmed Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title_short Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
title_sort silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365289/
https://www.ncbi.nlm.nih.gov/pubmed/18476011
http://dx.doi.org/10.1155/MBD.2002.307
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