Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines

A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl(2) is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562...

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Detalles Bibliográficos
Autores principales: Haines, Robert I., Murnaghan, Aleisha M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365294/
https://www.ncbi.nlm.nih.gov/pubmed/18475426
http://dx.doi.org/10.1155/MBD.2002.61
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author Haines, Robert I.
Murnaghan, Aleisha M.
author_facet Haines, Robert I.
Murnaghan, Aleisha M.
author_sort Haines, Robert I.
collection PubMed
description A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl(2) is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range.
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spelling pubmed-23652942008-05-12 Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines Haines, Robert I. Murnaghan, Aleisha M. Met Based Drugs Research Article A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl(2) is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365294/ /pubmed/18475426 http://dx.doi.org/10.1155/MBD.2002.61 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Haines, Robert I.
Murnaghan, Aleisha M.
Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title_full Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title_fullStr Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title_full_unstemmed Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title_short Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines
title_sort facile synthesis of cis-dichloro-(1,4,7-triazacyclononane) platinum(ii) and its screening against human ovarian cancer (sk-ov-3) and leukemia (k-562) cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365294/
https://www.ncbi.nlm.nih.gov/pubmed/18475426
http://dx.doi.org/10.1155/MBD.2002.61
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AT murnaghanaleisham facilesynthesisofcisdichloro147triazacyclononaneplatinumiianditsscreeningagainsthumanovariancancerskov3andleukemiak562celllines

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