Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S...

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Detalles Bibliográficos
Autores principales: Lukevics, Edmunds, Abele, Edgars, Arsenyan, Pavel, Abele, Ramona, Rubina, Kira, Shestakova, Irina, Domracheva, Ilona, Vologdina, Violetta
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365301/
https://www.ncbi.nlm.nih.gov/pubmed/18475424
http://dx.doi.org/10.1155/MBD.2002.45
Descripción
Sumario:Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.

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