Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S...

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Autores principales: Lukevics, Edmunds, Abele, Edgars, Arsenyan, Pavel, Abele, Ramona, Rubina, Kira, Shestakova, Irina, Domracheva, Ilona, Vologdina, Violetta
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365301/
https://www.ncbi.nlm.nih.gov/pubmed/18475424
http://dx.doi.org/10.1155/MBD.2002.45
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author Lukevics, Edmunds
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Rubina, Kira
Shestakova, Irina
Domracheva, Ilona
Vologdina, Violetta
author_facet Lukevics, Edmunds
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Rubina, Kira
Shestakova, Irina
Domracheva, Ilona
Vologdina, Violetta
author_sort Lukevics, Edmunds
collection PubMed
description Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.
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spelling pubmed-23653012008-05-12 Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides Lukevics, Edmunds Abele, Edgars Arsenyan, Pavel Abele, Ramona Rubina, Kira Shestakova, Irina Domracheva, Ilona Vologdina, Violetta Met Based Drugs Research Article Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2365301/ /pubmed/18475424 http://dx.doi.org/10.1155/MBD.2002.45 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lukevics, Edmunds
Abele, Edgars
Arsenyan, Pavel
Abele, Ramona
Rubina, Kira
Shestakova, Irina
Domracheva, Ilona
Vologdina, Violetta
Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title_full Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title_fullStr Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title_full_unstemmed Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title_short Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides
title_sort synthesis and cytotoxicity of silicon containing pyridine and quinoline sulfides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365301/
https://www.ncbi.nlm.nih.gov/pubmed/18475424
http://dx.doi.org/10.1155/MBD.2002.45
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