Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L-Valine and Kinetic Study of Copper(II) with Calf Thymus DNA

Five coordinated novel complexes of [Formula: see text] and [Formula: see text] have been synthesized from benzil and 1,3- diaminopropane- [Formula: see text] / [Formula: see text] complex and characterized by elemental analysis, i.r., n.m.r., e.p.r, molar conductance and u.v-vis, spectroscopy. The complexes are ionic in nature and exhibit pentaeoordinated geometry around the metal ion. The reaction kinetics of [Formula: see text] with calf thymus DNA was studied by u.v-vis, spectroscopy in aqueous medium. The complex after interaction with calf thymus DNA shows shift in the absorption spectrum and hypochromicity indicating an intercalative binding mode. The [Formula: see text] values have been calculated under pseudo-first order conditions. The redox behaviour of complex [Formula: see text] in the presence and in the absence of calf thymus DNA in the aqueous solution has been investigated by cyclic voltammetry. The cyclic voitammogram exhibits one quasi-reversible redox wave corresponding to [Formula: see text] / [Formula: see text] redox couple with [Formula: see text] values of -0.377 and -0.237 V respectively at a scan rate of 0.1V [Formula: see text] .On interaction with calf thymus DNA, the complex [Formula: see text] exhibits shifts in both [Formula: see text] as well as in [Formula: see text] values, indicating strong binding of the complex to the calf thymus DNA.