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Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity

To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with...

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Autores principales: Rodriguez-Barbero, A., Bosque, E., Rivas-Cabaero, L., Arévalo, M., López-Novoa, J. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365312/
https://www.ncbi.nlm.nih.gov/pubmed/18475436
http://dx.doi.org/10.1155/S096293519200005X
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author Rodriguez-Barbero, A.
Bosque, E.
Rivas-Cabaero, L.
Arévalo, M.
López-Novoa, J. M.
author_facet Rodriguez-Barbero, A.
Bosque, E.
Rivas-Cabaero, L.
Arévalo, M.
López-Novoa, J. M.
author_sort Rodriguez-Barbero, A.
collection PubMed
description To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg(−1) body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg(−1) body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity.
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spelling pubmed-23653122008-05-12 Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity Rodriguez-Barbero, A. Bosque, E. Rivas-Cabaero, L. Arévalo, M. López-Novoa, J. M. Mediators Inflamm Research Article To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg(−1) body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg(−1) body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2365312/ /pubmed/18475436 http://dx.doi.org/10.1155/S096293519200005X Text en Copyright © 1992 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rodriguez-Barbero, A.
Bosque, E.
Rivas-Cabaero, L.
Arévalo, M.
López-Novoa, J. M.
Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title_full Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title_fullStr Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title_full_unstemmed Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title_short Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
title_sort effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365312/
https://www.ncbi.nlm.nih.gov/pubmed/18475436
http://dx.doi.org/10.1155/S096293519200005X
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