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Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1992
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365312/ https://www.ncbi.nlm.nih.gov/pubmed/18475436 http://dx.doi.org/10.1155/S096293519200005X |
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author | Rodriguez-Barbero, A. Bosque, E. Rivas-Cabaero, L. Arévalo, M. López-Novoa, J. M. |
author_facet | Rodriguez-Barbero, A. Bosque, E. Rivas-Cabaero, L. Arévalo, M. López-Novoa, J. M. |
author_sort | Rodriguez-Barbero, A. |
collection | PubMed |
description | To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg(−1) body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg(−1) body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity. |
format | Text |
id | pubmed-2365312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1992 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23653122008-05-12 Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity Rodriguez-Barbero, A. Bosque, E. Rivas-Cabaero, L. Arévalo, M. López-Novoa, J. M. Mediators Inflamm Research Article To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg(−1) body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg(−1) body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2365312/ /pubmed/18475436 http://dx.doi.org/10.1155/S096293519200005X Text en Copyright © 1992 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rodriguez-Barbero, A. Bosque, E. Rivas-Cabaero, L. Arévalo, M. López-Novoa, J. M. Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title_full | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title_fullStr | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title_full_unstemmed | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title_short | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
title_sort | effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365312/ https://www.ncbi.nlm.nih.gov/pubmed/18475436 http://dx.doi.org/10.1155/S096293519200005X |
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