Endotoxin and cytokines in patients with gastrointestinal tract perforation

Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necr...

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Detalles Bibliográficos
Autores principales: Endo, S., Inada, K., Inoue, Y., Otsu, T., Kasai, T., Kuwata, Y., Hoshi, S., Yoshida, M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365315/
https://www.ncbi.nlm.nih.gov/pubmed/18475440
http://dx.doi.org/10.1155/S0962935192000097
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author Endo, S.
Inada, K.
Inoue, Y.
Otsu, T.
Kasai, T.
Kuwata, Y.
Hoshi, S.
Yoshida, M.
author_facet Endo, S.
Inada, K.
Inoue, Y.
Otsu, T.
Kasai, T.
Kuwata, Y.
Hoshi, S.
Yoshida, M.
author_sort Endo, S.
collection PubMed
description Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necrosis factor α (TNFα), rather than with the endotoxin level. The high interleukin 6 (IL-6) level was shown in septic patients and no correlation was observed between the IL-6 level and the clinical outcome. Plasma TNFα levels tended to change independently from endotoxin levels, suggesting that TNFα may have been locally produced in inflammatory lesions.
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spelling pubmed-23653152008-05-12 Endotoxin and cytokines in patients with gastrointestinal tract perforation Endo, S. Inada, K. Inoue, Y. Otsu, T. Kasai, T. Kuwata, Y. Hoshi, S. Yoshida, M. Mediators Inflamm Research Article Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necrosis factor α (TNFα), rather than with the endotoxin level. The high interleukin 6 (IL-6) level was shown in septic patients and no correlation was observed between the IL-6 level and the clinical outcome. Plasma TNFα levels tended to change independently from endotoxin levels, suggesting that TNFα may have been locally produced in inflammatory lesions. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2365315/ /pubmed/18475440 http://dx.doi.org/10.1155/S0962935192000097 Text en Copyright © 1992 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Endo, S.
Inada, K.
Inoue, Y.
Otsu, T.
Kasai, T.
Kuwata, Y.
Hoshi, S.
Yoshida, M.
Endotoxin and cytokines in patients with gastrointestinal tract perforation
title Endotoxin and cytokines in patients with gastrointestinal tract perforation
title_full Endotoxin and cytokines in patients with gastrointestinal tract perforation
title_fullStr Endotoxin and cytokines in patients with gastrointestinal tract perforation
title_full_unstemmed Endotoxin and cytokines in patients with gastrointestinal tract perforation
title_short Endotoxin and cytokines in patients with gastrointestinal tract perforation
title_sort endotoxin and cytokines in patients with gastrointestinal tract perforation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365315/
https://www.ncbi.nlm.nih.gov/pubmed/18475440
http://dx.doi.org/10.1155/S0962935192000097
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