Cytokine gene regulation by PGE(2), LTB(4) and PAF

The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review...

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Detalles Bibliográficos
Autores principales: Rola-Pleszczynski, M., Stankova, J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365316/
https://www.ncbi.nlm.nih.gov/pubmed/18475433
http://dx.doi.org/10.1155/S0962935192000024
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author Rola-Pleszczynski, M.
Stankova, J.
author_facet Rola-Pleszczynski, M.
Stankova, J.
author_sort Rola-Pleszczynski, M.
collection PubMed
description The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB (4), PGE (2) and PAF on cytokine gene expression.
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spelling pubmed-23653162008-05-12 Cytokine gene regulation by PGE(2), LTB(4) and PAF Rola-Pleszczynski, M. Stankova, J. Mediators Inflamm Research Article The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB (4), PGE (2) and PAF on cytokine gene expression. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2365316/ /pubmed/18475433 http://dx.doi.org/10.1155/S0962935192000024 Text en Copyright © 1992 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rola-Pleszczynski, M.
Stankova, J.
Cytokine gene regulation by PGE(2), LTB(4) and PAF
title Cytokine gene regulation by PGE(2), LTB(4) and PAF
title_full Cytokine gene regulation by PGE(2), LTB(4) and PAF
title_fullStr Cytokine gene regulation by PGE(2), LTB(4) and PAF
title_full_unstemmed Cytokine gene regulation by PGE(2), LTB(4) and PAF
title_short Cytokine gene regulation by PGE(2), LTB(4) and PAF
title_sort cytokine gene regulation by pge(2), ltb(4) and paf
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365316/
https://www.ncbi.nlm.nih.gov/pubmed/18475433
http://dx.doi.org/10.1155/S0962935192000024
work_keys_str_mv AT rolapleszczynskim cytokinegeneregulationbypge2ltb4andpaf
AT stankovaj cytokinegeneregulationbypge2ltb4andpaf

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