Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells

Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory...

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Detalles Bibliográficos
Autores principales: Sommerburg, Olaf, Grune, Tilman, Klee, Sabine, Ungemach, Fritz R., Siems, Werner G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365379/
https://www.ncbi.nlm.nih.gov/pubmed/18475499
http://dx.doi.org/10.1155/S0962935193000031
Descripción
Sumario:Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl(3). It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds.

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