Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells

Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory...

Descripción completa

Detalles Bibliográficos
Autores principales: Sommerburg, Olaf, Grune, Tilman, Klee, Sabine, Ungemach, Fritz R., Siems, Werner G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365379/
https://www.ncbi.nlm.nih.gov/pubmed/18475499
http://dx.doi.org/10.1155/S0962935193000031
_version_ 1782154153997369344
author Sommerburg, Olaf
Grune, Tilman
Klee, Sabine
Ungemach, Fritz R.
Siems, Werner G.
author_facet Sommerburg, Olaf
Grune, Tilman
Klee, Sabine
Ungemach, Fritz R.
Siems, Werner G.
author_sort Sommerburg, Olaf
collection PubMed
description Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl(3). It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds.
format Text
id pubmed-2365379
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-23653792008-05-12 Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells Sommerburg, Olaf Grune, Tilman Klee, Sabine Ungemach, Fritz R. Siems, Werner G. Mediators Inflamm Research Article Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl(3). It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds. Hindawi Publishing Corporation 1993 /pmc/articles/PMC2365379/ /pubmed/18475499 http://dx.doi.org/10.1155/S0962935193000031 Text en Copyright © 1993 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sommerburg, Olaf
Grune, Tilman
Klee, Sabine
Ungemach, Fritz R.
Siems, Werner G.
Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title_full Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title_fullStr Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title_full_unstemmed Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title_short Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
title_sort formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365379/
https://www.ncbi.nlm.nih.gov/pubmed/18475499
http://dx.doi.org/10.1155/S0962935193000031
work_keys_str_mv AT sommerburgolaf formationof4hydroxynonenalandfurtheraldehydicmediatorsofinflammationduringbromotrichlorornethanetreatmentofratlivercells
AT grunetilman formationof4hydroxynonenalandfurtheraldehydicmediatorsofinflammationduringbromotrichlorornethanetreatmentofratlivercells
AT kleesabine formationof4hydroxynonenalandfurtheraldehydicmediatorsofinflammationduringbromotrichlorornethanetreatmentofratlivercells
AT ungemachfritzr formationof4hydroxynonenalandfurtheraldehydicmediatorsofinflammationduringbromotrichlorornethanetreatmentofratlivercells
AT siemswernerg formationof4hydroxynonenalandfurtheraldehydicmediatorsofinflammationduringbromotrichlorornethanetreatmentofratlivercells

Ejemplares similares