Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these...

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Detalles Bibliográficos
Autores principales: Seow, W. Kim, Nakamura, Kazuhiro, Sugimura, Yukio, Sugimoto, Yukihiro, Yamada, Yasuyuki, Fairlie, David P., Thong, Y.H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365410/
https://www.ncbi.nlm.nih.gov/pubmed/18475522
http://dx.doi.org/10.1155/S0962935193000262
Descripción
Sumario:Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.

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