Cargando…

Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these...

Descripción completa

Detalles Bibliográficos
Autores principales: Seow, W. Kim, Nakamura, Kazuhiro, Sugimura, Yukio, Sugimoto, Yukihiro, Yamada, Yasuyuki, Fairlie, David P., Thong, Y.H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365410/
https://www.ncbi.nlm.nih.gov/pubmed/18475522
http://dx.doi.org/10.1155/S0962935193000262
Descripción
Sumario:Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.