Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these...

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Detalles Bibliográficos
Autores principales: Seow, W. Kim, Nakamura, Kazuhiro, Sugimura, Yukio, Sugimoto, Yukihiro, Yamada, Yasuyuki, Fairlie, David P., Thong, Y.H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365410/
https://www.ncbi.nlm.nih.gov/pubmed/18475522
http://dx.doi.org/10.1155/S0962935193000262
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author Seow, W. Kim
Nakamura, Kazuhiro
Sugimura, Yukio
Sugimoto, Yukihiro
Yamada, Yasuyuki
Fairlie, David P.
Thong, Y.H.
author_facet Seow, W. Kim
Nakamura, Kazuhiro
Sugimura, Yukio
Sugimoto, Yukihiro
Yamada, Yasuyuki
Fairlie, David P.
Thong, Y.H.
author_sort Seow, W. Kim
collection PubMed
description Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.
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spelling pubmed-23654102008-05-12 Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha Seow, W. Kim Nakamura, Kazuhiro Sugimura, Yukio Sugimoto, Yukihiro Yamada, Yasuyuki Fairlie, David P. Thong, Y.H. Mediators Inflamm Research Article Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis. Hindawi Publishing Corporation 1993 /pmc/articles/PMC2365410/ /pubmed/18475522 http://dx.doi.org/10.1155/S0962935193000262 Text en Copyright © 1993 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Seow, W. Kim
Nakamura, Kazuhiro
Sugimura, Yukio
Sugimoto, Yukihiro
Yamada, Yasuyuki
Fairlie, David P.
Thong, Y.H.
Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title_full Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title_fullStr Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title_full_unstemmed Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title_short Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
title_sort inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365410/
https://www.ncbi.nlm.nih.gov/pubmed/18475522
http://dx.doi.org/10.1155/S0962935193000262
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