Cytokines in Clinical and Experimental Transplantation

Allograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance o...

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Detalles Bibliográficos
Autores principales: Vossen, Ann C. T. M., Savelkoul, Huub F. J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365586/
https://www.ncbi.nlm.nih.gov/pubmed/18475587
http://dx.doi.org/10.1155/S0962935194000566
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author Vossen, Ann C. T. M.
Savelkoul, Huub F. J.
author_facet Vossen, Ann C. T. M.
Savelkoul, Huub F. J.
author_sort Vossen, Ann C. T. M.
collection PubMed
description Allograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance of allospecific graft tolerance. Furthermore, we discuss the feasibility of clinical graft function monitoring by measuring cytokines and the possibilities for intervention in the cytokine network in order to inhibit graft rejection and eventually obtain graft acceptance.
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spelling pubmed-23655862008-05-12 Cytokines in Clinical and Experimental Transplantation Vossen, Ann C. T. M. Savelkoul, Huub F. J. Mediators Inflamm Research Article Allograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance of allospecific graft tolerance. Furthermore, we discuss the feasibility of clinical graft function monitoring by measuring cytokines and the possibilities for intervention in the cytokine network in order to inhibit graft rejection and eventually obtain graft acceptance. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2365586/ /pubmed/18475587 http://dx.doi.org/10.1155/S0962935194000566 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vossen, Ann C. T. M.
Savelkoul, Huub F. J.
Cytokines in Clinical and Experimental Transplantation
title Cytokines in Clinical and Experimental Transplantation
title_full Cytokines in Clinical and Experimental Transplantation
title_fullStr Cytokines in Clinical and Experimental Transplantation
title_full_unstemmed Cytokines in Clinical and Experimental Transplantation
title_short Cytokines in Clinical and Experimental Transplantation
title_sort cytokines in clinical and experimental transplantation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365586/
https://www.ncbi.nlm.nih.gov/pubmed/18475587
http://dx.doi.org/10.1155/S0962935194000566
work_keys_str_mv AT vossenannctm cytokinesinclinicalandexperimentaltransplantation
AT savelkoulhuubfj cytokinesinclinicalandexperimentaltransplantation

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