Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane

The effect of nedocromil sodium on the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs) was investigated by measuring steady-state fluorescence anisotropy of 1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH) incorporated in the membrane. Our results show that nedocro...

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Detalles Bibliográficos
Autores principales: Kantar, A., Oggiano, N., Giorgi, P. L., Coppa, G. V., Gabbianelli, R., Bruni, S., Cutrona, F. M., Fiorini, R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365593/
https://www.ncbi.nlm.nih.gov/pubmed/18475598
http://dx.doi.org/10.1155/S0962935194000700
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author Kantar, A.
Oggiano, N.
Giorgi, P. L.
Coppa, G. V.
Gabbianelli, R.
Bruni, S.
Cutrona, F. M.
Fiorini, R.
author_facet Kantar, A.
Oggiano, N.
Giorgi, P. L.
Coppa, G. V.
Gabbianelli, R.
Bruni, S.
Cutrona, F. M.
Fiorini, R.
author_sort Kantar, A.
collection PubMed
description The effect of nedocromil sodium on the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs) was investigated by measuring steady-state fluorescence anisotropy of 1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH) incorporated in the membrane. Our results show that nedocromil sodium 300 μM significantly decreased membrane fluidity of PMNs. The decrease in membrane fluidity of PMNs induced by fMLP was abolished in the presence of nedocromil sodium. These data suggest that nedocromil sodium interferes with the plasma membranes of PMNs and modulates their activities.
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spelling pubmed-23655932008-05-12 Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane Kantar, A. Oggiano, N. Giorgi, P. L. Coppa, G. V. Gabbianelli, R. Bruni, S. Cutrona, F. M. Fiorini, R. Mediators Inflamm Research Article The effect of nedocromil sodium on the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs) was investigated by measuring steady-state fluorescence anisotropy of 1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH) incorporated in the membrane. Our results show that nedocromil sodium 300 μM significantly decreased membrane fluidity of PMNs. The decrease in membrane fluidity of PMNs induced by fMLP was abolished in the presence of nedocromil sodium. These data suggest that nedocromil sodium interferes with the plasma membranes of PMNs and modulates their activities. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2365593/ /pubmed/18475598 http://dx.doi.org/10.1155/S0962935194000700 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kantar, A.
Oggiano, N.
Giorgi, P. L.
Coppa, G. V.
Gabbianelli, R.
Bruni, S.
Cutrona, F. M.
Fiorini, R.
Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title_full Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title_fullStr Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title_full_unstemmed Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title_short Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
title_sort effect of nedocromil sodium on polymorphonuclear leukocyte plasma membrane
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365593/
https://www.ncbi.nlm.nih.gov/pubmed/18475598
http://dx.doi.org/10.1155/S0962935194000700
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