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CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa
In the allergic mucosa, there is a significant increase in numbers of CD25(+) cells and activated eosinophils. To determine whether a link exists between the activated T-lymphocytes and tissue eosinophils in nasal allergy, we studied CD25(+) cells in the nasal mucosa and compared the levels of solub...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1995
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365614/ https://www.ncbi.nlm.nih.gov/pubmed/18475632 http://dx.doi.org/10.1155/S0962935195000251 |
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author | Horiguchi, S. Hisamatsu, K. Tasaka, K. |
author_facet | Horiguchi, S. Hisamatsu, K. Tasaka, K. |
author_sort | Horiguchi, S. |
collection | PubMed |
description | In the allergic mucosa, there is a significant increase in numbers of CD25(+) cells and activated eosinophils. To determine whether a link exists between the activated T-lymphocytes and tissue eosinophils in nasal allergy, we studied CD25(+) cells in the nasal mucosa and compared the levels of soluble IL-2 receptor (sIL-2R) both in the serum and the nasal secretions, and further investigated expression of CD11b on eosinophils in the nasal lavage fluids and peripheral blood of patients with nasal allergy. We also examined the effects of the culture supernatant of Con A- and IL-2-activated T-lymphocytes on CD11b expression on eosinophils in the present study. The concentration of sIL-2R in the nasal secretions from patients with Japanese cedar pollinosis (JCP) was significantly higher than that from normal subjects (p < 0.01). The sIL-2R level was significantly higher in the nasal secretions than in the sera in patients (p < 0.01), and CD11b expression on eosinophils from nasal hvage fluid was significandy higher than that of eosinophils from peripheral blood of the same individuals (p < 0.01). The activated T-lymphocytes promoted eosinophil activation with upregulation of CD11b in vitro, and eosinophils in the nasal secretions from patients significantly expressed more CD11b in vivo. These results indicate that activation of T-lymphocytes is linked to eosinophil activation in nasal allergy. |
format | Text |
id | pubmed-2365614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23656142008-05-12 CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa Horiguchi, S. Hisamatsu, K. Tasaka, K. Mediators Inflamm Research Article In the allergic mucosa, there is a significant increase in numbers of CD25(+) cells and activated eosinophils. To determine whether a link exists between the activated T-lymphocytes and tissue eosinophils in nasal allergy, we studied CD25(+) cells in the nasal mucosa and compared the levels of soluble IL-2 receptor (sIL-2R) both in the serum and the nasal secretions, and further investigated expression of CD11b on eosinophils in the nasal lavage fluids and peripheral blood of patients with nasal allergy. We also examined the effects of the culture supernatant of Con A- and IL-2-activated T-lymphocytes on CD11b expression on eosinophils in the present study. The concentration of sIL-2R in the nasal secretions from patients with Japanese cedar pollinosis (JCP) was significantly higher than that from normal subjects (p < 0.01). The sIL-2R level was significantly higher in the nasal secretions than in the sera in patients (p < 0.01), and CD11b expression on eosinophils from nasal hvage fluid was significandy higher than that of eosinophils from peripheral blood of the same individuals (p < 0.01). The activated T-lymphocytes promoted eosinophil activation with upregulation of CD11b in vitro, and eosinophils in the nasal secretions from patients significantly expressed more CD11b in vivo. These results indicate that activation of T-lymphocytes is linked to eosinophil activation in nasal allergy. Hindawi Publishing Corporation 1995-03 /pmc/articles/PMC2365614/ /pubmed/18475632 http://dx.doi.org/10.1155/S0962935195000251 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Horiguchi, S. Hisamatsu, K. Tasaka, K. CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title | CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title_full | CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title_fullStr | CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title_full_unstemmed | CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title_short | CD25(+) T-lymphocytes induce CD11b on eosinophils in allergic nasal mucosa |
title_sort | cd25(+) t-lymphocytes induce cd11b on eosinophils in allergic nasal mucosa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365614/ https://www.ncbi.nlm.nih.gov/pubmed/18475632 http://dx.doi.org/10.1155/S0962935195000251 |
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