Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma

The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R a...

Descripción completa

Detalles Bibliográficos
Autores principales: lorenzo, G. Di, Mansueto, P., Melluso, M., Morici, G., Norrito, F., Cigna, D., Candore, G., Caruso, C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365642/
https://www.ncbi.nlm.nih.gov/pubmed/18475650
http://dx.doi.org/10.1155/S0962935195000433
_version_ 1782154194883444736
author lorenzo, G. Di
Mansueto, P.
Melluso, M.
Morici, G.
Norrito, F.
Cigna, D.
Candore, G.
Caruso, C.
author_facet lorenzo, G. Di
Mansueto, P.
Melluso, M.
Morici, G.
Norrito, F.
Cigna, D.
Candore, G.
Caruso, C.
author_sort lorenzo, G. Di
collection PubMed
description The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis.
format Text
id pubmed-2365642
institution National Center for Biotechnology Information
language English
publishDate 1995
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-23656422008-05-12 Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma lorenzo, G. Di Mansueto, P. Melluso, M. Morici, G. Norrito, F. Cigna, D. Candore, G. Caruso, C. Mediators Inflamm Research Article The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis. Hindawi Publishing Corporation 1995-07 /pmc/articles/PMC2365642/ /pubmed/18475650 http://dx.doi.org/10.1155/S0962935195000433 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
lorenzo, G. Di
Mansueto, P.
Melluso, M.
Morici, G.
Norrito, F.
Cigna, D.
Candore, G.
Caruso, C.
Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title_full Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title_fullStr Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title_full_unstemmed Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title_short Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
title_sort serum levels of soluble il-2r, cd4 and cd8 in bronchial asthma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365642/
https://www.ncbi.nlm.nih.gov/pubmed/18475650
http://dx.doi.org/10.1155/S0962935195000433
work_keys_str_mv AT lorenzogdi serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT mansuetop serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT mellusom serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT moricig serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT norritof serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT cignad serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT candoreg serumlevelsofsolubleil2rcd4andcd8inbronchialasthma
AT carusoc serumlevelsofsolubleil2rcd4andcd8inbronchialasthma

Ejemplares similares