The effect of lipocortin 1 on neutrophil deformability

Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability,...

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Detalles Bibliográficos
Autores principales: Drost, E. M., MacNee, W., Smith, S. F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365789/
https://www.ncbi.nlm.nih.gov/pubmed/18475714
http://dx.doi.org/10.1155/S0962935196000257
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author Drost, E. M.
MacNee, W.
Smith, S. F.
author_facet Drost, E. M.
MacNee, W.
Smith, S. F.
author_sort Drost, E. M.
collection PubMed
description Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.
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spelling pubmed-23657892008-05-12 The effect of lipocortin 1 on neutrophil deformability Drost, E. M. MacNee, W. Smith, S. F. Mediators Inflamm Research Article Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo. Hindawi Publishing Corporation 1996-06 /pmc/articles/PMC2365789/ /pubmed/18475714 http://dx.doi.org/10.1155/S0962935196000257 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Drost, E. M.
MacNee, W.
Smith, S. F.
The effect of lipocortin 1 on neutrophil deformability
title The effect of lipocortin 1 on neutrophil deformability
title_full The effect of lipocortin 1 on neutrophil deformability
title_fullStr The effect of lipocortin 1 on neutrophil deformability
title_full_unstemmed The effect of lipocortin 1 on neutrophil deformability
title_short The effect of lipocortin 1 on neutrophil deformability
title_sort effect of lipocortin 1 on neutrophil deformability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365789/
https://www.ncbi.nlm.nih.gov/pubmed/18475714
http://dx.doi.org/10.1155/S0962935196000257
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