Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients

Two deacetyl-thymosin α(1) analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)(21)]deacetyl-thymosin α(1) and [Phe(4Br)(21)]deacetyl-thymosin α(1), respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of...

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Detalles Bibliográficos
Autores principales: Abiko, T., Sekino, H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365812/
https://www.ncbi.nlm.nih.gov/pubmed/18475743
http://dx.doi.org/10.1155/S0962935196000439
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author Abiko, T.
Sekino, H.
author_facet Abiko, T.
Sekino, H.
author_sort Abiko, T.
collection PubMed
description Two deacetyl-thymosin α(1) analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)(21)]deacetyl-thymosin α(1) and [Phe(4Br)(21)]deacetyl-thymosin α(1), respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)(21)deacetyl-thymosin α(1), demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α(1), but the other analogue, [D-Phe(4Br)(21)]deacetyl-thymosin α(1), showed no restorative effect under the same conditions.
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spelling pubmed-23658122008-05-12 Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients Abiko, T. Sekino, H. Mediators Inflamm Research Article Two deacetyl-thymosin α(1) analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)(21)]deacetyl-thymosin α(1) and [Phe(4Br)(21)]deacetyl-thymosin α(1), respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)(21)deacetyl-thymosin α(1), demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α(1), but the other analogue, [D-Phe(4Br)(21)]deacetyl-thymosin α(1), showed no restorative effect under the same conditions. Hindawi Publishing Corporation 1996-09 /pmc/articles/PMC2365812/ /pubmed/18475743 http://dx.doi.org/10.1155/S0962935196000439 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abiko, T.
Sekino, H.
Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title_full Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title_fullStr Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title_full_unstemmed Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title_short Syntheses of two deacetyl-thymosin α(1) analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
title_sort syntheses of two deacetyl-thymosin α(1) analogues and their effects on low e-rosette-forming lymphocytes of uraemic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365812/
https://www.ncbi.nlm.nih.gov/pubmed/18475743
http://dx.doi.org/10.1155/S0962935196000439
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