Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels

The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppresse...

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Detalles Bibliográficos
Autores principales: Pukhalsky, A. L., Bliacher, M. S., Danilina, A. V., Kalashnikova, E. A., Lopatina, T. K., Fedorova, I. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365819/
https://www.ncbi.nlm.nih.gov/pubmed/18475748
http://dx.doi.org/10.1155/S0962935196000592
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author Pukhalsky, A. L.
Bliacher, M. S.
Danilina, A. V.
Kalashnikova, E. A.
Lopatina, T. K.
Fedorova, I. M.
author_facet Pukhalsky, A. L.
Bliacher, M. S.
Danilina, A. V.
Kalashnikova, E. A.
Lopatina, T. K.
Fedorova, I. M.
author_sort Pukhalsky, A. L.
collection PubMed
description The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan(®)). It is possible that the imunofan treatment could prevent some postvaccinal complications.
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spelling pubmed-23658192008-05-12 Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels Pukhalsky, A. L. Bliacher, M. S. Danilina, A. V. Kalashnikova, E. A. Lopatina, T. K. Fedorova, I. M. Mediators Inflamm Research Article The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan(®)). It is possible that the imunofan treatment could prevent some postvaccinal complications. Hindawi Publishing Corporation 1996-12 /pmc/articles/PMC2365819/ /pubmed/18475748 http://dx.doi.org/10.1155/S0962935196000592 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pukhalsky, A. L.
Bliacher, M. S.
Danilina, A. V.
Kalashnikova, E. A.
Lopatina, T. K.
Fedorova, I. M.
Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title_full Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title_fullStr Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title_full_unstemmed Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title_short Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
title_sort changes in tnf and il-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365819/
https://www.ncbi.nlm.nih.gov/pubmed/18475748
http://dx.doi.org/10.1155/S0962935196000592
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