Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells

This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TN...

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Detalles Bibliográficos
Autores principales: Rougier, F., Cornu, E., Gachard, N., Praloran, V., Denizot, Y.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365834/
https://www.ncbi.nlm.nih.gov/pubmed/18472825
http://dx.doi.org/10.1080/09629359791730
Descripción
Sumario:This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-α on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.

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