Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells

This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TN...

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Detalles Bibliográficos
Autores principales: Rougier, F., Cornu, E., Gachard, N., Praloran, V., Denizot, Y.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365834/
https://www.ncbi.nlm.nih.gov/pubmed/18472825
http://dx.doi.org/10.1080/09629359791730
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author Rougier, F.
Cornu, E.
Gachard, N.
Praloran, V.
Denizot, Y.
author_facet Rougier, F.
Cornu, E.
Gachard, N.
Praloran, V.
Denizot, Y.
author_sort Rougier, F.
collection PubMed
description This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-α on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.
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spelling pubmed-23658342008-05-12 Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells Rougier, F. Cornu, E. Gachard, N. Praloran, V. Denizot, Y. Mediators Inflamm Research Article This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-α on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis. Hindawi Publishing Corporation 1997-06 /pmc/articles/PMC2365834/ /pubmed/18472825 http://dx.doi.org/10.1080/09629359791730 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rougier, F.
Cornu, E.
Gachard, N.
Praloran, V.
Denizot, Y.
Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title_full Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title_fullStr Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title_full_unstemmed Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title_short Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells
title_sort tumour necrosis factor-alpha (tnfα) stimulates the growth of human bone marrow stromal cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365834/
https://www.ncbi.nlm.nih.gov/pubmed/18472825
http://dx.doi.org/10.1080/09629359791730
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