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Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis

The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to...

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Detalles Bibliográficos
Autores principales: Mealy, K., Clooney, A., Marks, P., Hennessy, T., Jackson, J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365840/
https://www.ncbi.nlm.nih.gov/pubmed/18472837
http://dx.doi.org/10.1080/09629359791965
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author Mealy, K.
Clooney, A.
Marks, P.
Hennessy, T.
Jackson, J.
author_facet Mealy, K.
Clooney, A.
Marks, P.
Hennessy, T.
Jackson, J.
author_sort Mealy, K.
collection PubMed
description The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, α, β and γ globulin fractions on serum electrophoresis, complement C(3) and transferrin levels. Danazol increased the α1, α2 and β1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis.
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spelling pubmed-23658402008-05-12 Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis Mealy, K. Clooney, A. Marks, P. Hennessy, T. Jackson, J. Mediators Inflamm Research Article The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, α, β and γ globulin fractions on serum electrophoresis, complement C(3) and transferrin levels. Danazol increased the α1, α2 and β1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis. Hindawi Publishing Corporation 1997-02 /pmc/articles/PMC2365840/ /pubmed/18472837 http://dx.doi.org/10.1080/09629359791965 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mealy, K.
Clooney, A.
Marks, P.
Hennessy, T.
Jackson, J.
Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title_full Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title_fullStr Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title_full_unstemmed Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title_short Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
title_sort effects of anabolic steroids on acute phase responses in intra-abdominal sepsis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365840/
https://www.ncbi.nlm.nih.gov/pubmed/18472837
http://dx.doi.org/10.1080/09629359791965
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