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Augmentation of protective immune responses against viral infection by oral administration of schizophyllan
An oral administration of fungal polysaccharide schizophyllan has augmented protective immune responses to Sendai virus infection in mice and the rodshaped DNA virus of Penaeus japonicus (RV-PJ) infection in Kuruma shrimps. When schizophyllan was administered orally at a dose of 50 or 100 mg/kg body...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1997
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365866/ https://www.ncbi.nlm.nih.gov/pubmed/18472856 http://dx.doi.org/10.1080/09629359791596 |
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author | Itoh, Wataru |
author_facet | Itoh, Wataru |
author_sort | Itoh, Wataru |
collection | PubMed |
description | An oral administration of fungal polysaccharide schizophyllan has augmented protective immune responses to Sendai virus infection in mice and the rodshaped DNA virus of Penaeus japonicus (RV-PJ) infection in Kuruma shrimps. When schizophyllan was administered orally at a dose of 50 or 100 mg/kg body weight per day, the survival rates after virus challenge were significantly higher than those of the control groups. High phagocytic activities were observed in the haemocytes of the schizophyllan-fed shrimps.These results suggest that schizophyllan confers effective protection against viral infection by increasing antiviral immune responses, and that it could be used to boost immunity to virus infection in animals or in invertebrates. |
format | Text |
id | pubmed-2365866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23658662008-05-12 Augmentation of protective immune responses against viral infection by oral administration of schizophyllan Itoh, Wataru Mediators Inflamm Research Article An oral administration of fungal polysaccharide schizophyllan has augmented protective immune responses to Sendai virus infection in mice and the rodshaped DNA virus of Penaeus japonicus (RV-PJ) infection in Kuruma shrimps. When schizophyllan was administered orally at a dose of 50 or 100 mg/kg body weight per day, the survival rates after virus challenge were significantly higher than those of the control groups. High phagocytic activities were observed in the haemocytes of the schizophyllan-fed shrimps.These results suggest that schizophyllan confers effective protection against viral infection by increasing antiviral immune responses, and that it could be used to boost immunity to virus infection in animals or in invertebrates. Hindawi Publishing Corporation 1997-11 /pmc/articles/PMC2365866/ /pubmed/18472856 http://dx.doi.org/10.1080/09629359791596 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Itoh, Wataru Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title | Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title_full | Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title_fullStr | Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title_full_unstemmed | Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title_short | Augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
title_sort | augmentation of protective immune responses against viral infection by oral administration of schizophyllan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365866/ https://www.ncbi.nlm.nih.gov/pubmed/18472856 http://dx.doi.org/10.1080/09629359791596 |
work_keys_str_mv | AT itohwataru augmentationofprotectiveimmuneresponsesagainstviralinfectionbyoraladministrationofschizophyllan |