Inhalation toxicity of (1→3)-β-D glucan: recent advances

To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all typ...

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Detalles Bibliográficos
Autores principales: Fogelmark, Birgitta, Sjöstrand, Margareta, Williams, David, Rylander, Ragnar
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365867/
https://www.ncbi.nlm.nih.gov/pubmed/18472855
http://dx.doi.org/10.1080/09629359791587
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author Fogelmark, Birgitta
Sjöstrand, Margareta
Williams, David
Rylander, Ragnar
author_facet Fogelmark, Birgitta
Sjöstrand, Margareta
Williams, David
Rylander, Ragnar
author_sort Fogelmark, Birgitta
collection PubMed
description To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin.
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spelling pubmed-23658672008-05-12 Inhalation toxicity of (1→3)-β-D glucan: recent advances Fogelmark, Birgitta Sjöstrand, Margareta Williams, David Rylander, Ragnar Mediators Inflamm Research Article To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin. Hindawi Publishing Corporation 1997-11 /pmc/articles/PMC2365867/ /pubmed/18472855 http://dx.doi.org/10.1080/09629359791587 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fogelmark, Birgitta
Sjöstrand, Margareta
Williams, David
Rylander, Ragnar
Inhalation toxicity of (1→3)-β-D glucan: recent advances
title Inhalation toxicity of (1→3)-β-D glucan: recent advances
title_full Inhalation toxicity of (1→3)-β-D glucan: recent advances
title_fullStr Inhalation toxicity of (1→3)-β-D glucan: recent advances
title_full_unstemmed Inhalation toxicity of (1→3)-β-D glucan: recent advances
title_short Inhalation toxicity of (1→3)-β-D glucan: recent advances
title_sort inhalation toxicity of (1→3)-β-d glucan: recent advances
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365867/
https://www.ncbi.nlm.nih.gov/pubmed/18472855
http://dx.doi.org/10.1080/09629359791587
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